Acetyl l carnitine nerve health neuropathy benefit and review supplement, diabetic neuropathy, nerve health
Benefit of for sexual enhancement and erectile function, mental boost
November 11 2016

Acetyl L-Carnitine and diabetic neuropathy
An evaluation from two 52-week randomized placebo-controlled clinical diabetic neuropathy trials testing acetyl l carnitine demonstrated that treatment is beneficial in alleviating symptoms (particularly pain) and improves nerve fiber regeneration and vibration perception in patients with established diabetic neuropathy. The study was published in Diabetes Care journal.

Nerve regeneration influence
Effect of Acetyl L Carnitine on Axonal Sprouting Following Donor Nerve Injury Distal to an End-to-Side Neurorrhaphy Model. J Reconstr Microsurg. 2009. Kokkalis ZT, Soucacos PN, Terzis JK. International Institute of Reconstructive Microsurgery, Eastern Virginia Medical School, Norfolk, Virginia. This study investigated the hypothesis that acetyl L carnitine (ALCAR) could have a significant effect on nerve regeneration after end-to-side neurorrhaphy. The ability of the ALCAR to enhance nerve regeneration. Twenty-five Sprague-Dawley rats were randomized to five groups of five animals each, in which three different types of donor injury. The combination of an injury model of the donor nerve (crush injury) with administration of acetyl L carnitine proved to be a significantly more potent stimulus for regeneration than the control (placebo) group, as measured by behavioral, muscle morphometric, electrophysiological, and histomorphometric studies.

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Additional products formulated by Dr. Sahelian include Mind Power Rx which has DMAE.

Acetyl l carnitine is a stabilized form of the amino acid metabolite L Carnitine and is utilized in the same manner in the body. ALCAR plays an important role in protecting and supporting brain function. I may also be useful in sexual energy enhancement.

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Q. I don’t have a lot of knowledge in medicine or chemical terminology. What is the difference between the l-carnitine and the acetyl l carnithine? Are they the same thing? If different from each other, how that difference affects any person taking those products? Can they be taken in a combination or make no difference either one you take? Because they are two names for something, that looks to me like the same product; I’m kind of confused. Basically; I know, that there is a difference on price between these two products for whatever reason, but that’s all I know.
A. Acetyl carnitine and carnitine play crucial roles in the human body. These nutrients shuttle acetyl groups and fatty acids into mitochondria for energy production. Without carnitine, fatty acids cannot easily enter into mitochondria. The acetyl group of acetyl l carnitine is used to form acetyl-CoA, the most important intermediary in the generation of energy from amino acids, fats, and carbohydrates. Therefore, acetyl l carnitine serves as an energy reservoir of acetyl groups and both acetylcarnitine and carnitine help improve energy production. The acetyl group of acetyl l carnitine is also used to make the important brain chemical acetylcholine. Some studies suggest that perhaps acetyl l carnitine can even act as a neurotransmitter itself. Those who take carnitine pills notice an increase in physical energy, but not as much mental energy. Acetyl l carnitine has a significantly more immediate and noticeable mental effect than carnitine because it crosses into the brain much better. The mind boosting effect of acetyl l carnitine is often noticed within a few hours, or even within an hour. Most people report feeling mentally sharper, having more focus and being more alert. Some find a mild mood enhancement.

The mind boosting effect of acetyl l carnitine is often noticed within a few hours, or even within an hour. Most people report feeling mentally sharper, having more focus and being more alert. Some find a mild mood enhancement. it may be used as an overall mind booster. The typical dosage is 250 mg once a day or a few times a week. Choline product converts into acetylcholine and is a brain booster.

Alzheimer’s disease
This nutrient may be helpful in those with Alzheimer’s disease. Galantamine pill is also used for this condition.

ADHD patients may partially respond to this nutrient, and there may be natural ways to treat this childhood condition.

Those who have a form of fertility problem where acetyl l carnitine could be useful.

Acetyl l carnitine beneficial for macular degeneration
Improvement of visual functions and fundus alterations in early age-related macular degeneration treated with a combination of acetyl-L-carnitine, n-3 fatty acids, and coenzyme Q10.
Ophthalmologica. 2005. Ophthalmic Neuroscience Program, Department of Ophthalmology, University of Rome ‘La Sapienza’, Rome, Italy.
The aim of this randomized, double-blind, placebo-controlled clinical trial was to determine the efficacy of a combination of acetyl-L-carnitine, n-3 fatty acids, and coenzyme Q10 (Phototrop) on the visual functions and fundus alterations in early age-related macular degeneration (AMD). One hundred and six patients with a clinical diagnosis of early AMD were randomized to the treated or control groups. The primary efficacy variable was the change in the visual field mean defect (VFMD) from baseline to 12 months of treatment, with secondary efficacy parameters: visual acuity (Snellen chart and ETDRS chart), foveal sensitivity as measured by perimetry, and fundus alterations as evaluated according to the criteria of the International Classification and Grading System for AMD. The mean change in all four parameters of visual functions showed significant improvement in the treated group by the end of the study period. Decrease in drusen-covered area of treated eyes was also statistically significant as compared to placebo. These findings strongly suggested that an appropriate combination of compounds which affect mitochondrial lipid metabolism, may improve and subsequently stabilize visual functions, and it may also improve fundus alterations in patients affected by early AMD.

Mind enhancement, memory increase
Can this mind enhancer be taken with other herbs that have an influence on memory and alertness such as bacopa monnieri?
Probably but we suggest you try each separately and if you combine them, use lower dosages of bacopa monnieri.

For sexual enhancement, mood and energy
Can acetyl l-carnitine, a natural nutrient, be just as good for aging men as testosterone? In this Italian study, a total of 120 men (age range 60 to 74) were randomized into three groups. Group 1 was given testosterone, the second group was given propionyl-L-carnitine 2 grams a day plus acetyl L-carnitine 2 grams a day. The third group was given a placebo. Testosterone, carnitines and placebo were given for 6 months. Testosterone and carnitines significantly improved performance on several tests that measure sexual function, mood, and energy. These tests included nocturnal penile tumescence, Depression Melancholia Scale score, and fatigue scale score. Carnitines proved significantly more active than testosterone in improving sexual function. Testosterone significantly increased the prostate volume and testosterone levels; carnitines did not. Carnitines and testosterone proved effective for as long as they were administered. No major side effects were reported within the 6 month study period.

I understand ALC can be useful for sexual energy improvement, what about tongkat ali herb or yohimbe bark extract, are they helpful, too?
Certainly. These herbs are very potent and effective for this purpose.

Thyroid conditions
I have read that individuals with thyroid disease should avoid taking the alc and ala supplement but the information does not state what the side effect is. I am 75 yrs old, have taken the supplement 500mg ALC and ALA 200mg combo w/breakfast) for more than 10 yrs without any apparent side effect that I am aware of. I am in good health and very active. I also take 75 mcg levothyroid daily when awakening for hypothyroidism. What is your advice regarding this alc / ala supplement?
We prefer to use lower dosages but different doctors have different opinions.

Acetyl l carnitine side effect, safety, caution
Side effects of acetyl l carnitine include overstimulation at dosages greater than 500 mg. Nausea is another acetyl l carnitine side effect.

Q. Is headache a l acetyl l carnitine side effect?
A. In a few people, headache may be a cause of a high dose of acetyl l carnitine side effect.

Combining with other supplements, interactions
Is it too high a dose to combine coq10 100 mg with acetyl l carnitine 500 mg?
For most people, yes. We suggest limiting it to CoQ10 30mg and acetyl l carnitine to 300 mg or less.