Arginine dosage for blood pressure and impotence, review of benefits and side effects, available in 1 gram pill and also in powder, influence on growth hormone
l arginine and citrulline, which works better to reduce hypertension? How often should you take the pills or powder? How long the effects last?
December 11 2016

Benefits of Arginine for blood pressure and hypertension management
Supplemental arginine reduces pulmonary resistance and blood pressure, as well as improving the ventilatory response to carbon dioxide production, according to results from a Japanese study. However, the benefit of arginine supplement for blood pressure reduction are short lived and not practical. We are not sure how long the nitric oxide stays around to keep dilating the blood vessels.

L arginine and blood pressure
Although many studies have been done evaluating the role of supplement l arginine in blood pressure treatment, the jury is still out as to the effectiveness of l arginine for blood pressure control and whether it is worthwhile to consume so many grams a day. There may be better alternatives to high dose l arginine consumption for the treatment of hypertension.

I just ordered Passion Rx. In the general list of ingredients arginine is not listed. I am diabetic and am on an ACE inhibitor. Can I take Passion Rx without concern that I will be consuming L-arginine?
Passion Rx does not have this amino acid. We don’t have any data to support the claim that small amounts of this amino acid supplement cannot be used with an ACE inhibitor.

Kidney health
Arginine supplementation improves renal function in patients with chronic heart failure. This was the finding of a study from another Japanese university.

Polish researchers have found that arginine supplementation increases exercise tolerance in stable coronary artery disease patients.

Arginine, a semi-essential amino acid, is involved in numerous areas of human biochemistry, including ammonia detoxification, hormone secretion, and immune modulation. This amino acid is also well known as a precursor to nitric oxide (NO), a key component of endothelial-derived relaxing factor, an endogenous messenger molecule involved in a variety of endothelium-dependent physiological effects in the cardiovascular system. L-arginine is a protein amino acid present in the proteins of all life forms. It is classified as a semi-essential or conditionally essential amino acid. This means that under normal circumstances the body can synthesize sufficient L-arginine to meet physiological demands. This amino acid, by itself, does not work well for erectile dysfunction.

Arginine and impotence
Thus far we are not impressed with the ability of arginine to have a marked influence on impotence treatment.

A medical doctor’s experience with arginine
According to his website, Dr. Ray Sahelian, M.D., the world’s top expert in natural supplements, says he hasn’t had good results with l arginine. “I have tried doses of up to 12 grams without much of an immediate effect. Perhaps others respond better, but as for me, I like the total sexual enhancement from Passion Rx so much more.”

Purchase L Arginine pills and powder
L Arginine is a semi-essential amino acid synthesized by the body from ornithine. This amino acid supports protein synthesis as it is involved in the transport and storage of nitrogen. Among many functions, it is used by the body to produce creatine.

Arginine studies do not indicate this amino acid is a good sexual enhancer as well as yohimbe bark herb.

Usage: Take 1 to 6 arginine supplement tablets daily, or as directed by your qualified health consultant.
Serving Size 1 Tablet
L Arginine 750 mg tablet
purchase Arginine dosage 750 mg pill discount

l arginine function and metabolism
It is is involved in protein synthesis. Arginine is involved in the detoxification of ammonia formed during the nitrogen catabolism of amino acids via the formation of urea. In addition, L-arginine is a precursor in the formation of nitric oxide, Creatine, polyamines, L-glutamate, and L-proline. Those interested in arginine may also wish to consider Citrulline.
Arginine is similar to citrulline and it is difficult to know whether one supplement offers an advantage over the other. Arginine lysine and function arginine aspartate are various forms of this amino acid.

Mechanism of Action
The most likely explanation for the modest effectiveness of arginine is its conversion into nitric oxide. As discussed in Chapter 2, nitric oxide is converted into cGMP, which becomes the secondary messenger that causes smooth muscle relaxation, resulting in more blood going into the genital organs, which leads to erections. However, nitric oxide is metabolized quite rapidly, which may explain why taking arginine does not lead to consistent or prolonged erections.

Sustained release l arginine
The effects of sustained-release-L-arginine formulation on blood pressure and vascular compliance in 29 healthy individuals.
Altern Med Rev. 2006.
Since L-arginine is the body’s only substrate for nitric oxide synthesis, adequate L-arginine must be present for proper nitric oxide production. In this open label trial, a group of 29 asymptomatic individuals were given L-arginine (1,050 mg, as Perfusia-SR, a sustained-release preparation) twice daily (total 2.1 g daily) for one week. Systolic blood pressure was reduced in 62 percent of participants compared to baseline, with a non-significant mean decrease in all patients of 4 mm Hg. Diastolic blood pressure was reduced in 69 percent of participants. In the 10 individuals who were borderline or hypertensive (systolic > 130 or diastolic > 85), there was a mean systolic reduction of 11 mm Hg, while normotensives had a mean systolic decrease of only 0.22 mm Hg. Diastolic blood pressure was decreased a non-significant 4.9 mm Hg in borderline or hypertensives and 4.5 mm Hg in normotensives. This is the first study showing a moderate dose of sustained-release L-arginine can improve endothelial function and blood pressure.

l citrulline l arginine relation
L-ornithine and L-citrulline are precursors in the synthesis of L-arginine which is converted to urea and L-ornithine via the enzyme arginase. The portion of L-arginine that is not converted to urea enters the circulation, and is distributed to the various tissues and metabolized as discussed above.

L Arginine aspartate
Chronic arginine aspartate supplementation in runners reduces total plasma amino acid level at rest and during a marathon run.
Eur J Nutr. 1999. Swiss Federal Institute of Technology, Zurich.
Athletes consume l arginine and/or aspartate as potential nutritional ergogenics. Their metabolic effects are controversial and there is some evidence that ingestion of large doses of single amino acids can adversely affect the nitrogen balance or induce an amino acid imbalance. Nevertheless, the general metabolic influence of an arginine aspartate supplementation during a prolonged exercise bout has not yet been investigated. The aim of this study was, therefore, to investigate the general metabolic impact of a chronic supplementation with arginine aspartate in endurance-trained athletes at rest and during a marathon run. Fourteen endurance-trained runners participated in this field study which was carried out according to a double-blind crossover design. 15 g of arginine aspartate or a carbohydrate-based placebo were supplemented daily for 14 days before a marathon run. The plasma level of carbohydrate (glucose, lactate, pyruvate) and fat metabolites (fatty acids, glycerol, beta-hydroxybutyrate), cortisol, insulin, ammonia, lactate dehydrogenase, and creatine kinase as well as the respiratory exchange ratio were unaffected by the supplementation. In contrast, the plasma level of somatotropic hormone, glucagon, urea, and arginine were significantly increased, and the level of most of the remaining plasma amino acids as well as their sum was significantly reduced. There was no obvious metabolic benefit derived from the chronic supplementation with arginine aspartate.

Interactions with medications
Is arginine safe to take while on thyroxine medication?
Each person reacts differently so it is not easy to say, the dosage makes a difference and other supplements or medications used, along with the overall health of the person. However, the amino acid is a safe supplement generally and combines well with other supplements.

Arginine and preeclampsia
Dietary supplementation with L-arginine or placebo in women with pre-eclampsia.
Departments of Obstetrics and Gynecology, Ulleval University Hospital, Kirkeveien Oslo, Norway.
To investigate the effect of dietary intake of the NO-donor L-arginine on the diastolic blood pressure in women with pre-eclampsia. A randomized double-blind study was designed to compare the effect of L-arginine and placebo in pre-eclamptic women with gestational length ranging from 28+0 to 36+0 weeks. The women received orally 12 g of L-arginine or placebo daily for up to 5 days. The primary end-point was to identify a difference in diastolic blood pressure alteration between the two groups after 2 days of intervention. Secondary end-points included the interval from study start to delivery, the proportion of women delivered after 2, 5 or 10 days from treatment start and mean birth weight. There was no statistically significant alteration in diastolic blood pressure in the L-arginine group compared with the placebo group after 2 days of treatment. No differences in the proportions of women delivered by day 2, 5 or 10 after study start, in the mean interval from study start to delivery, or in mean birth weight percentile were observed between the two groups. CONCLUSIONS: Oral L-arginine supplementation did not reduce mean diastolic blood pressure after 2 days of treatment compared with placebo in pre-eclamptic patients with gestational length varying from 28 to 36 weeks. Whether L-arginine treatment could be clinically beneficial for the mother or the fetus if started earlier in the disease process than for the women in our study remains to be seen.

Arginine studies and review
Effects of early enteral arginine supplementation on resuscitation of severe burn patients.
Burns. 2006; Institute of Burn Research, Southwest Hospital, The Third Military Medical University, State Key Laboratory of Trauma, Burns, and Combined Injury (SKLTBC), Chongqing, PR China.
To investigate the effects of dietary supplementation of l-arginine on shock in severely burned patients. Forty-seven severely burned patients due to various causes with a total burn surface area (TBSA) more than 50% each admitted in early postburn phase (within 10h postburn) were included in this study. All patients were treated by the traditional resuscitation program of our institute. After the nasogastric feeding tube was placed, they were randomly divided into three groups-(1) group A400 (n=16): giving gastrointestinal feeding with 500ml 5% GNS, containing l-Arginine (400mg/kgday) at equal pace with fluid resuscitation; (2) group A200 (n=16): giving gastrointestinal feeding with 500ml 5% GNS containing l-Arginine (200mg/kg each day); (3) group C: giving gastrointestinal feeding with 500ml 5% GNS without any supplementation. The feeding started within 12h after burn and lasted for 72h, the feeding rate was controlled by an enteral feeding pump. The following parameters were observed on days (PBD) 1-4: serum nitric oxide content (NO), mean arterial blood pressure (MAP), oxygenation index (PO(2)/FiO(2)), and arterial blood content of lactic acid (LA). Gastric mucosal blood flow was measured by laser Doppler flow-metry on PBD1 and PBD2. (1) Enteral feeding of l-Arginine did not change MAP of severely burned patients, with no difference in MAP between the l-Arg supplemented and control groups. There were significant changes of the l-Arginine supplemented groups (A400 and A200), with an increased gastric mucosa blood flow, oxygenation index, and a decreased LA content in arterial blood, compared with the control group. (3) The serous NO content was significantly decreased in the A400 group on PBD2-4, and in the A200 group on PBD4 compared with the control group. Enteral feeding with l-arginine supplementation on early stage of burn decreases NO production to a relatively normal level and exerts beneficial effects on the resuscitation of burned shock.

Hemorrhagic shock and lung injury
Recipient treatment with L-arginine attenuates donor lung injury associated with hemorrhagic shock.
Transplantation. 2009; Preissler G, Löhe F, Ebersberger U, Bittmann I, Angele MK. Department of Surgery, Ludwig-Maximilians-University of Munich, Klinikum Grosshadern, Munich, Germany.
L-arginine treatment during reperfusion increases the production of endothelial nitric oxide and thus ameliorates ischemia-reperfusion injury. Although fulfilling ideal donor criteria, pulmonary graft function of lungs harvested from donors subjected to HSR is impaired, but improves significantly when l-arginine is administered during reperfusion.

Q. Does l arginine supplement make herpes worse?
   A. We are not able to find meaningful human research with l arginine and herpes.

Q. What dose is arginine sold at? Which is better arginine powder or l arginine 1000 mg capsule?
A. You can find arginine 1000 mg, arginine 750 mg, arginine 500 mg and a number of other arginine dosages. It really does not matter whether you take 3 to 5 capsules of l arginine 1000 mg or a teaspoon of l arginine powder.

Q. What is your opinion of the book the Arginine Solution?
A. We have not read the Arginine Solution book, but from the cover it may promise more than it delivers.

Sperm, semen
Q. Is arginine in ejaculate and semen? If I take arginine supplement, will large amount be found in the semen ejaculate?
A. We are not sure.

Liquid vs capsule or powder
Q. Is arginine liquid preferable to arginine powder or capsule?
A. We have not seen any research with arginine liquid and for the time being we find the capsule or powder to be well absorbed.

Women, use by females
Q. Can women take it safely?

A. Yes, arginine can be taken by a woman.

Q.  I read some of your information on L-arginine. Are you perhaps aware that after 20 years of research, Dr Ann De Wees Allen, the leading authority in L-arginine research (including 250,000 participants with no negative side affects) received the only patent for L-arginine on her product Proargi9 in 2003? Proving it to be a blind amino acid, she developed a low glycemic 32 step sophisticated rider. Consequently, the FDA has allowed her to make 15 health claims; one of which is, “is more well tolerated than L-arginine alone.”
A. We are not sure what “more well tolerated than L arginine ” means since arginine is quite well tolerated by itself and no arginine side effects have been reported thus far. We also have not seen a FDA ruling on arginine with this product regarding 15 health claims. Furthermore we have no idea what is meant by “proving it to be a blind amino acid, she developed a low glycemic 32 step sophisticated rider.”

Can you comment on the possible adverse effects that arginine supplementation may have on asthmatics? I have mild asthma that is well controlled and am willing to lose a small degree of control for a short period of time in order to experiment with arginine. However, if a catastrophic event is possible, I would not take the risk.
We are not aware of any studies that have found taking arginine supplement to influence asthma. However, the final decision is up to your doctor.

I see that Passion Rx does not contain arginine. Can I take them together? Can one take such supplements with horny goat weed?
Yes, arginine supplements can be taken along with Passion Rx and horny goat weed.

Perhaps older readers need to be warned about argenine if they have calcified arteries, etc? Please see this article below on the safety of argenine for older folks and others who fall into the patient categories below. “At the Johns Hopkins Medical Institutions in Baltimore, Dr. Steven P. Schulman and his colleagues examined 153 heart attack patients; 77 patients were 60 years old or older. The patients were randomly given a 3g dosage of L-arginine 3 times a day or a matching dose of placebo for about 6 months. It was believed that L-arginine helped decreasing the load on the heart vessels by promoting the nitric oxide availability. “Our hypothesis was that L-arginine would be beneficial,” said study co-author Dr. Gary Gerstenblith, a professor of medicine at Johns Hopkins, He added “L-arginine administration did not improve cardiac remodeling over a six-month period,” After six month researchers found out that administration of L-arginine did not improve ejection-fraction or even enhance vascular stiffness as was expected. On the contrary, patients taking L-arginine were at increased risk of death more than those who took placebo. The death of six patients above 60 years old- taking L-arginine caused the early termination of this study. Researchers concluded that L-arginine, when added to patients’ therapies following a myocardial infarction, does not improve vascular stiffness measurements or improve left ventricular function.
We are not big proponents for the long term use of arginine supplements in the treatment of cardiovascular disease. The influence of arginine on blood pressure is probably not long lasting.

I have been taking l-arginine for the past few months, and I only have 20 tablets left. I take one a day. I am going to start taking Passion Rx, so is it advisable to take l-arginine and Passion Rx together?
It is best to learn how each supplement works by itself for a few days. Arginine is a safe supplement can can be taken with most other supplements without problems.

Can you comment on the arginine benefits by ProArgi9? There is a website that makes these claims: ProArgi9 is the ONLY arginine product declared FDA SAFE! The following patented legal claims on ProArgi9 have been approved by the FDA and FTC:
* Reduces risk of heart disease
* Increases muscle mass
* Reduces adipose tissue body fat
* Stimulation of the release of the most important anti-aging hormone in the body, growth hormone
* Improves immune system
* Reduces healing time of injuries (particularly bone)
* Natural alternative to Viagra
The FDA and the FTC do not allow such claims to be made about the health benefit of arginine. The statements on the website you mention regarding ProArgi9 are not correct and actually violate FDA and FTC rules.