Pregnenolone dosage and DHEA health benefits – How safe is this hormone? Danger, caution, risks, and use as hormone replacement therapy
Testosterone, progesterone, estrogen

Pregnenolone dosage available over the counter ranges from 10 mg up to 100 mg. There is a danger using any dosage above 10 mg. We do not suggest taking it together with DHEA since their benefits and side effects can add up unless you are using tiny amounts of each, such as less than 2 or 3 mgs.

Health Benefits
Some people find pregnenolone improves energy levels, vision, memory, clarity of thinking, wellbeing, and often sexual enjoyment. Some women report lessening of hot flashes or premenstrual symptoms. Studies in rodents show it to be one of the most effective and powerful memory boosters. Pregnenolone may increase levels of acetylcholine in the hippocampus and other memory regions in the brain. However, it is not risk-free.

A good number of individuals have reported enhancement of visual perception. Colors are brighter and clearer. Patterns are more noticeable. Looking becomes more enjoyable. However, not everyone seems to be attuned to this perceptual enhancement.

Addison’s disease, adrenal exhaustion
Q. You caution against the use of routine pregnenolone supplements. One exception seemed to be for persons suffering from extreme adrenal issues. Do you mean Addison’s only? Or would you consider extreme adrenal exhaustion fatigue to be in that same category? And my second question… Would you consider James Wilson to be a reliable source for information on adrenal exhaustion fatigue?
A. We are not familiar with James Wilson. There is a wide range of adrenal function, from Addison’s disease all the way to perfect adrenal function and everything in between. There can be a certain amount of adrenal insufficiency that doctors may not categorize as Addison’s. Just like any organ, the adrenal gland can function at various levels.

Prostate cancer patient
Q. Do you think a man with prostate cancer can take pregnenolone? If so would you suggest long term or short term use? Please specify how long short or long term would be.
   A. Although the effects on the prostate gland are not as direct as testosterone, we don’t recommend any kind of steroid hormone in a person who has prostate cancer.

Rheumatoid arthritis
Q. I am writing because I have rheumatoid arthritis and it has been suggested that pregnenolone might be beneficial. I have managed to control my symptoms for the last 10 years with nutritional suppliments but now am experiencing more inflamation. I have had success with low doses of methylprednisolone. I don’t want to take steroids over a long period of time.
A. Pregnenolone is a powerful hormone with some benefits and risks. Please see the cautions before use, and discuss with your doctor. We can’t advise whether you should or should not take pregnenolone for your rheumatoid arthritis.

Side effects of high dose
Pregnenolone side effects research studies are ongoing and as soon as more studies are published we will review this information and suggest appropriate and safe dosages of this natural hormone.

Overstimulation and insomnia
Irritability, anger or anxiety could occur after several days
Acne and increased pimples. There may be an acne remedy with diet and foods, does what you eat influence your skin health?
Possible scalp hair loss if used daily for prolonged periods
Irregularities of heart rhythm, palpitations on high doses
Unknown effects on the thyroid gland or other organs

I ordered 2 different kinds of products: dosage of 10 mg dissolveable sublingual tabs – and dosage of 50 mg tablets that are swallowed. I’ve only taken the 50 mg maybe 4 times total over a period of about 4 weeks. The 10 mg sublingual I’ve taken about 8-10 times total over the same period. My concern is that I’ve noticed over the past week or so that I’ve been experiencing MARKED heart palpitations / arrhythmias, particularly when lying down at night. It concerned me and I had no idea why… until I realized the only thing I’ve been doing differently (lately) is taking the pregnenolone. I then researched online for a possible connection and voila! – there was your article. So I’m simply giving (anecdotal?) personal evidence that I think supports that connection.

I have been a fan of pregnenolone for years, but have also been extra careful on what amount to take, and the frequency I take it. It causes agitation, and interferes with my sleep. I am a healthy 59ish, and just discovered something that helps to counter the effects. It is so simple. roasted sesame oil.

Pregnenolone Caution, danger, risks, testimonials
We’re still in the early stages of learning about pregnenolone and its full effects on the human body. It is best to proceed with caution until more information is available. This means using the lowest effective dose and seeking supervision by a knowledgeable health care provider. There are some medical or psychiatric conditions where pregnenolone can be used temporarily and then stopped. With this conservative approach, it is unlikely that any problems would arise. Our major uncertainty at this time involves the long-term use of pregnenolone as hormone replacement therapy, especially if high doses are used. Pregnenolone can also cause heart palpitations in high doses.
With time, as more and more people use this hormone, we’ll have a fuller understanding of its benefits and side effects. Those who have already found pregnenolone to be helpful in terms of mood elevation, stress reduction, arthritis help, visual and auditory enhancement, and so forth, but are concerned about unknown long-term effects, may feel more comfortable using pregnenolone only as needed and frequently taking time off from it. Taking these “hormone holidays” will mitigate any potential unknown risks.
Daily use of pregnenolone over prolonged periods should be no more than 1 to 3 mg unless you are closely followed by a health care practitioner familiar with the clinical uses of this hormone. Current dosage available over the counter, such as 25, 50, or 100 mg are TOO high. If you purchase a 10 mg pill or capsule, take a portion of it if you plan to take it on a regular basis.

I am consulting a practitioner who recommends pregnenolone treatment. Having read your information about potential dangers of using more than very small amounts, and the cardiac risks, I mentioned your work to him. In his response, he was suggesting that his mentor has treated 7,000 plus patients without any heart problems occurring. He was also suggesting that maybe the people who have problems didn’t actually need pregnenolone in the first place, not having health problems, and hadn’t been tested or retested. I am trying to make my mind up independently, but it is difficult when there is a dearth of reliable research.
There are various opinions on the benefits and risks of dietary supplements and hormones. Ultimately it is up to the consumer, having read and learned as much as they can, to decide which expert’s opinion to rely on.

My Dr suggested I try pregnenolone if taking an adrenal supplement did not help my symptoms. I’m at the end of three weeks of supplementing with adrenal and have not found the amount of relief I had been hoping for. I found your web site and the concern about heart palpitations with the supplement. I already supplement with Magnesium Malate for a variety of symptoms including heart palpitations which I’ve had on and off for many years. It seems to keep them at bay. Should I venture into trying this hormone if I’ve already got a tendency to this condition? FYI: I am a 55-year-old female with a long history of complaints that seem to be endocrine related.

I am a 30 year old female of good health who was suffering associated stress from a high-paced and stressful work environment. As a precaution (there were no marked symptoms at the time presenting), my mother urged me to visit the well renowned endocrinologist in our area who took a battery of blood tests to check my adrenal functioning among other things. The results were all within normal ranges but with expected shortages in certain areas but nothing too alarming presented. My doctor prescribed both Pregnenolone and DHEA for their positive effects, however it was two months later that on a hot day when I had eaten and drunk little, I fainted. I had never fainted in all my life before (and I have been under plenty physically stressful conditions before). It began with anxiety and I broke out in a cold sweat. I experienced light-headedness and before I knew it I was out, once for about 20 seconds and then again for over a minute. My blood tests all came back normal. It may be worthwhile to mention, the only medication I take is the contraceptive pill.Since then (it was four weeks ago) I have been experiencing severe dizziness that had been most debilitating. The dizziness has been lasting at least 4 – 6 hours at a stretch and has been occurring every two or three days. I have ruled out inner ear infection, iron deficiency and seem to have regular heart rhythms following a post fainting check-up.As a child I suffered this similar dizziness (they lasted in progressive 3 – 4 days periods) and although many tests were conducted back then, nothing proved conclusive and the doctors said to treat it as a migraine headache. My mother said it always occurred when I had been “over stimulated” as a child. I have not had one such headache in almost twenty years until Pregnenelone was prescribed in 30mg doses to me. Having now read your cautionary tale on Pregnenelone, I am more convinced than ever, that my fainting was induced by Pregnenelone and that the dizziness that has occurred is the Pregnenelone working itself out my system (my doctor seems to think the fainting and dizziness are related even though the dizziness does not result in light-headedness or anxiety).I was wondering whether any side effects of fainting and dizziness have ever presented in other people taking Pregnenelone? For weeks before I fainted I had experienced a strange sensation akin to lightheaded-ness (but not quite) in the morning about 2 hours following taking the Pregnenelone. It felt like “something was happening” in my head (most difficult to describe – my thinking was “maybe I am hungry and should eat again”).It seems that as of today the dizziness may have started abating with the spell only lasting 2 hours and being slightly less severe.

What is a Steroid?
A steroid is chemical substance with four carbon ring structures attached to each other in a very specific way. Cortisol, DHEA, testosterone, pregnenolone, progesterone, and estrogen are all steroid hormones that chemically look very similar to each other in terms of their backbone. However, they differ from each other in only small ways, and even tiny changes in the chemical make up of a substance can make enormous differences in how it functions and what role it plays in the chemical factories of our bodies. For instance, testosterone, the male hormone, is only slightly different chemically from estrogen, the female hormone. Yet that slight difference causes men to grow facial hair and women to develop breasts. Androstenedione hormone is no longer available over the counter since the FDA made it not legal without a prescription.

Q. I was wondering since it is a “steroid”, does it increase strength or mass?
   A. Pregnenolone is a steroid, and converts into progesterone and DHEA. Although I am not aware of studies that have tested it in terms of increasing muscle mass, it probably has some effect, although not as direct as androgens.

Is Pregnenolone different that Progesterone?
Pregnenolone is converted in the body to progesterone and these two hormones have some overlapping similarities, but we still don’t know exactly how their effects overlap. Pregnenolone is also converted into DHEA, which, in turn may convert into androstenedione, testosterone, and estrogens. 7-keto dhea is a supplement related to DHEA and is also available online without a prescription.

What form is best?
Oral pregnenolone pills work well. Sublingual or micronized are also good options.

Can I take pregnenolone if I’m already on DHEA, estrogens, or other hormones?
Since both DHEA and pregnenolone  have some similar effects (however, they have differences, too), you should lower your dose of DHEA when you go on pregnenolone. The lowering of the dose should by the same amount as the pregnenolone dose. Before you add pregnenolone, though, make sure you try it separately to see what kind of effects it has on you, Once you know how you react to DHEA and pregnenolone separately, you can then combine them. The amount of conversion of pregnenolone to estrogens is not fully known.

Pregnenolone research and clinical trials
Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation.
Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. University of California, San Francisco School of Medicine, San Francisco, CA, USA. Psychoneuroendocrinology. 2004 May.
Pregnenolone is the major steroid precursor in humans. It is also a “neurosteroid” and possesses intrinsic behavioral and brain effects in animals, affecting the GABA(A) and other receptors. In two preliminary studies, we sought to characterize its tolerability and psychotropic effects in humans. In Study 1, 17 normal volunteers received pregnenolone and placebo for 4 weeks each (15 mg PO per day x2 weeks followed by 30 mg PO per day x2 weeks, vs. placebo x4 weeks) in a within-subject, double-blind, cross-over design, with a 4 week drug-free washout period separating the two arms. Subjects’ behavioral responses were assessed at the beginning and end of the 4-week pregnenolone arm and the 4-week placebo arm. Pregnenolone was generally well-tolerated but, by itself, had no significant effects on mood, memory, self-rated sleep quality or subjective well-being. In Study 2, 11 subjects from Study 1 received a single dose of diazepam immediately following completion of Study 1 in order to assess, in a between groups design, the impact of 4-weeks’ pre-treatment with pregnenolone vs. placebo on the acute sedative, amnestic and anxiolytic effects of this benzodiazepine. Pregnenolone-pretreated subjects showed significantly less sedation following diazepam; this effect was clinically apparent. Diazepam’s amnestic effects were non-significantly attenuated, and ratings of anxiety were unaffected. These pilot data, based on small samples, raise the possibility that chronically administered pregnenolone antagonizes certain acute effects of benzodiazepines and may enhance arousal via antagonist or inverse agonist actions at the benzodiazepine / GABA(A) receptor complex. Further larger-scale studies, utilizing a broader range of doses and experimental conditions, are warranted.

Pregnenolone supplementation, use in children
I am a doctor writing from Germany. Do you hold the use of pregnenolone  in the treatment of the concentration-weakness of children? It seems to work namely, but isn’t it contraindicated ? Or is it effective as normal basis-component of the hormone-synthesis without creating negative feedback problems?
   A. Pregnenolone is a powerful hormone and we would not recommend its use in children unless they have adrenal insufficiency.

Q. My son is 9 yrs old and suffers from a very rare condition called congenital adrenal hypoplasia.  This basically means he has no adrenal cortex at all and receives replacement therapy of hydrocortisone and fludrocortisone.  The complexity of the other 40 odd hormones produced in the cortex and their pathways are such that these other hormones are not added to this replacement regime.  If DHEA is the most abundant of hormones in the body and given the increased understanding of it and its interaction in the body, is not logical that some sort of replacement therapy would be offered to people suffering from adrenal insufficiency.  It would seem that a hormone related to moods, coping, blood sugar level management,, stress, testosterone synthesis would be needed by people who do not produce a drop.  Any thoughts would be greatly appreciated.
   A. The medical profession has not focused replacement of natural hormones for adrenal malfunction. Pregnenolone is the “grandmother adrenal hormone” from which all other adrenal hormones are made, while DHEA is the son of pregnenolone. It does seem reasonable to assume that perhaps replacing pregnenolone or DHEA might offer advantages that cortisones alone may not provide. The research on this is very limited but replacing or combining one or both of these hormones is theoretically a reasonable approach while under the care of an endocrinologist.

Q. I read about pregnenolone information by Dr. Sahelian. I understood that pregnenolone can have undesired side effects related to increasing DHEA and thus testosterone. I did not see to see a description of its proper use and possible side effects in people whole have below range DHEA and low free testosterone (and other reproductive hormones). I am hypothyroid on Armour and cytomel, with maladapted phase II adrenal fatigue. I also have DHEA that is a 1 range (3-10 ng/ml). My hormones are also in a precarious situation : free Testost 7 (5-20 pg/ml); Androsten 97 (75-400pg/ml); borderline low estradiol, estriol. And, strangely, elevated progesterone 800 (65-500pg/ml Luteal). My integrative medicine physician has suggested 10 mg 3x a week for a month of pregnenolone. I wondered if this situation differed from the warning not to take more than 5mg a day. I did have palpitations today, the first day I took it. But, I was not certain if it was from the cytomel, which I have just started using in the last few days and have been adjusting my dosage.
A. Pregnenolone can cause heart rhythm palpitations even on 10 mg, especially when combined with other medicines. You may wish to ask your doctor to read the page to see whether lower dosages may be more appropriate.

Is Prenenolone a safe replacement for Prednisone, when Prednisone has been contraindicated for a medical condition?
Pregnenlone is not a substitute for prednisone, they may have some overlapping effects but they also have quite different influences on the body. This hormone is much less understood than prednisone.

Q. You may be interested in additional data backing up your cautions on your web page. I had been taking 50 mgs of DHEA and pregnenolone each for about 9 months when I went in for a routine physical exam. The exam turned up hyperthyroidism and atrial flutter – neither of which had existed in any prior physicals. So, another profound ‘thanks;’ this time for your internet article. With the information it contained, I was able to alert my physician as to the probable cause of both conditions which was most helpful in reaching an accurate diagnosis. Fortunately, with medication and 2 cardioversions, both conditions have now been eliminated. As you might guess, I’ve learned a lesson about charging off on my own.

Can you tell me if DHEA or pregnenolone will develop “unwanted feminine character in men”. And if it is so, can my body undo the effect if I stop taking them.
They may cause both masculine (ie hair loss on the scalp) and perhaps feminine (breast tissue) depending on how you metabolize and how much you take, and most of the time the effects reverse with time.

I have been taking pregnenolone for 7 years now. I started when I began menopause and had terrible hot flashes. At that point I would have to take up to 180 mg. at a time to totally get rid of the hot flashes. It also gave me a great sense of well being and energy. I continued on that pregnenolone dosage for about 3 months, on a daily basis, and then reduced it to 50 mg a day and was still free from hot flashes and all other menopausal symptoms. I continued to take 50 mg daily of pregnenolone, occasionally taking a break off a few weeks here and there, or a few days off and on, but basically have been taking pregnenolone 50 mg on an almost daily basis for 7 years. I have never had any pregnenolone side effects. No palpitations. My hair has thinned a bit, but I don’t know if that would have happened anyway from age. What I am wondering, is if I can give pregnenolone to my 8 yr old female dog who is not fixed and
still goes into heat. It seems that each time she comes out of heat, she has a few weeks afterwards where her hormones are a bit out of control and she goes into false pregnancy. The vet wants me to get her spade, but before I do that, I thought pregnenolone might help her, the same way it helped me. The vet doesn’t know anything about it. Also, I was under the impression that pregnenolone is not retained in the tissues and that excess unneeded amounts are excreted. My gynecologist told me pregnenolone is safe in so much as that it is not retained in the liver tissue. Would this be true for the rest of the body as well?
We think taking this high dosage of pregnenolone for so long is a gamble and the long term effects a few more years from now are not known, including the potential risk for cancer. Keep us updated. As to using pregnenolone in a dog, this is outside of our range of knowledge since we don’t deal with animals. With most hormones in most people, taking the least amount that works is often the best option.

Excerpt from Pregnenolone: Nature’s Feel Good Hormone, reprinted with permission from the author, Dr. Ray Sahelian
In March of 1996, I learned that pregnenolone was just starting to be sold over the counter. I already knew that it was a hormone, and that some mice studies had found it to be a potent memory enhancer, but I had no idea what effect it had on humans. I called a number of my colleagues, but none had personally taken this hormone. No one seemed to know what it did, Having a strong sense of curiosity, and a bent towards adventure, I purchased a bottle of 10 milligram (mg) pills.

I should mention that before I write about supplements, I first try them myself. In addition to experimenting with DHEA, I have done so with melatonin and creatine. Treating patients with these supplements and studying the published research are important, but there’s no substitute for a personal trial. Can one be a competent romance novelist never having been passionately in love?

I first tried one pill in the morning and felt no effect. I continued taking 10 mg each morning for the next few days. Nothing. A year earlier, when I was experimenting with DHEA, I had an increase in energy the very first day I had taken 10 mg. Thinking to myself that perhaps pregnenolone didn’t have a noticeable influence on the human brain, I was about to give up. Curiosity urged me to continue. I increased the dosage to 20 mg each morning. I could now barely tell something was going on, perhaps I was a little more alert, but the effect was subtle.

A few days later, I increased the dosage to 30 mg and went about my routine, forgetting that I had taken it. Based on the experience of the previous few days, I didn’t expect to feel anything significant. I was considering putting an end to my pregnenolone experience in order to go on to another hormone or nutrient. However, that evening, while taking a stroll with a friend on the beachfront walk in Venice, California, I could feel something clearly happening. A mellow, steady, persistent feeling of well being, like a mild euphoria, had imperceptibly come on. Even though I normally feel good, this was different, and better. I became more conscious of my surroundings. Flowers growing in the front gardens of the ocean homes seemed brighter and prettier. I stopped to touch them, and sniffed a yellow colored rose in full bloom. A mosaic on the door of a beach house caught my eye. Examining it closer, I noticed that it was a scene of tall redwood trees with a curving blue stream running through the middle. My friend graciously accommodated my request that we stare at this mosaic and observe all of its fine details. It dawned on me that I had walked by this house many times before without paying much attention to this artwork. As I continued walking with my friend, my attention focused on the architecture of the homes. I started noticing the patterns of the stones, the shapes of windows, doorways, and porticos, and other details. The palm trees lining the walk appeared Caribbean island like picturesque. Everything seemed more beautiful and intriguing. I felt a sense of childish wonder, that “everything was okay”. How special and enchanting life could be!

I didn’t take any pregnenolone the next day, yet my sense of well being continued, but on a more subtle level. During a midday break, as I sat on my office chair lost in my thoughts, staring out through the balcony at the slow, undulating waves melting into the jetty rocks, I reflected about the previous evening’s delightful experience. A number of thoughts, ideas, and possibilities raced through my brain. Pregnenolone was so interesting, and so unknown. I wondered what kind of response this non-prescription, perception enhancing hormone would receive from the public, the medical establishment, the government, and the media. Would it be accepted or scorned? I also considered all the potential uses of this hormone in the fields of psychiatry and medicine, and how it could be helpful in restoring youthful awareness to older individuals whose production of this hormone has declined with the decades.

Learning more about pregnenolone became my passion. I started recommending it to patients and friends who were willing to give it a try. I talked to everyone I knew who might have used this hormone. Over the next few months, I contacted many more colleagues. Only a few had used pregnenolone in their practices, and in most cases their experience was limited. I then did a complete and thorough review of the scientific literature, looking at long buried studies dating back to the 1940’s.

Since my first days of experimentation, I have tried a number of pregnenolone products and a variety of forms, including pills, capsules, micronized capsules, sublingual tablets, and skin creams. There are often subtle, and not so subtle, distinctions among different forms, and different brands. I’ve also tried a variety of dosages. Initially, it took me a few days, and 30 mg, to feel the effects of pregnenolone, but now I can notice the effects even on as low a dosage as 5 mg, and sometimes within an hour of dosing. I have taken pregnenolone at home, in the office, on sunny days, cloudy days, while walking in the mist, in heavy downpours, on the beach, hiking in the mountains, listening to music, at parties, eating out, traveling in Italy, meandering through a shopping mall, and a variety of other settings. Furthermore, I have interviewed prominent researchers in the field, and I continue to evaluate the latest published research. I and a colleague, Dr. Karlis Ullis, are doing clinical evaluations of many patients on this hormone. In addition, I am cooperating with the Southwest College of Naturopathic Medicine in Tempe, Arizona, on a study evaluating the role of pregnenolone and premenstrual syndrome. In the following chapters, you will find detailed information never before published.

I’m 39 years old, and therefore too young to take pregnenolone regularly. But I am currently taking this hormone about once a week, in the range of 5 mg. I plan to do so until my late forties or fifties, when I begin using it more or less frequently. Hopefully, by then, we’ll have a much better understanding of this once forgotten, yet fascinating, hormone.

I am a 4o year old female with a 20 some odd year history of rheumatoid arthritis. I have been in and out of remission many times. However, I began to experience the symptoms that are common in either hyperthyroid or adrenal stain (these included dry skin, hair loss / slow growth, fatigue, occasional arrhythmia) so I had my homeopath do some investigating. It turns out thyroid levels are good but DHEA and pregnenolone levels were low (44 and 6 respectively). My homeopath has suggested a regime that includes, but not limited to, DHEA 10mg twice daily pregnenolone 5mg twice daily and pantothenic acid 500mg. So in doing some checking, I came across your website which makes me a bit concerned that I am not as informed as I should be about the therapies suggested. I should note that I do not take drugs (natural or synthetic) unless all dietary interventions have failed. That said, I proceed with caution this situation. Should I be concerned about the possibility of arrhythmia as a side effect given my history? Should this therapy increase my pregnenolone levels without effecting my body’s natural ability to produce this hormone in the long run like prednisone (ie. should I assume that this will become necessary long term therapy or will this stimulate my body’s own production)? Should I expect that this therapy might exacerbate the lack of hair growth?
We cannot predict what would occur to your health, benefit or harm, but we suggest your doctor review the pages on these hormones if not already acquainted.

I am writing for advice about pregenenolone. Please help. I will make this inquiry as short as possible. I am a 53-year-old female biomedical researcher (molecular biologist) suffering from a 17-year lower esophageal pain disorder robbing me of my ability to eat. After umpteen specialists in several medical fields … it was by happenstance that taking Synthroid for hypothyroidism improved the pain. A doctor then approved that I take both testosterone and DHEA. These too helped not only with energy levels but also with pain! I discovered pregnenolone in my local healthfood store. Before reading your website, I took 50-150 mg/day for ~ 5 days. I felt great! I had not felt that joyfully and energetically alive since being in my late teens early 20’s. The drawback was pregnenolone and wine caused massive insomnia and low grade headaches at night. I have one brand of wine with dinner 3 nights per week. It causes less esophageal pain that non-alcoholic (Fre’) wine. It is literally the only thing with any substantial flavor that I can ingest. Otherwise my diet consists of plain roasted nuts, flax seed oil, safflower oil, non-fat organic milk, rice milk, plain corn tortilla chips, avocados, and water. Now reading your website and a few others that admonish NOT to take more than 1-5 mg of pregnenolone per day and not every day (but take breaks) that makes complete and utter sense to me! My question: If I reduce the dose to 1 mg or at most 5 mg per day (perhaps three days per week—M,W, F) should I still experience insomnia at night or headaches? Or … is the only way to know this simply to try it. I really do believe at the really high doses it had helped with my lower esophageal pain. I would take only nonalcoholic wine, but I love the rich complexity of flavor of my Fetzer Gerweisterminer.
It is not possible to predict with certainty, but it is unlikely that low dosages below 3 mg would cause insomnia if the pills are taken in the morning.

I am working with prescribed 25 mg 7 Keto DHEA once a day plus Pregnelone 50 mg once a day my lab values show normal range DHEA at 121 and pregnenolone 10. She states that she wants my DHEA to improve to 250 and Pregnenolone between 80-100. I am 45 year old female, experiencing hormonal PMS and weight gain. Should I take one or the other? It seems Pregnelone has less side effects.
This is not a decision we can make for you, but we suggest you and your health care provider read the cautions on these hormone supplement use.

I’m a 58 yr old female – always enjoyed good health, strong, on no medications, but for several months I am so fatigued, run down, tired even after 8-9 hrs. sleep, feel as tho I drag through the day. I adjusted my diet, exercise regimen, and added some great supplements: multi-b, b-12 patch, 3,000 mg Vit.C, cal/mag / pot + Vit. D sublingually. I  am STILL drained (except for a couple of days after the B-12 patch). I went to the doctor’s office, she said blood tests came out within normal range. However, I read an article from a physican that said if the tests look “normal range” and the person still presents with all negative symptoms and still feels bad, the tests are more likely to be faulty, not the patient’s symptoms, and should be treated accordingly and not ignored. I was thinking about getting some DHEA / Pregnenalone sublingual liquid drops put out by Arrowhead Health Works in California. I am currently on Combi-Patch hormone replacement. I would like to know: What is the difference between sublingual LIQUID drops and sublingual pills? Don’t they both end up in the stomach to some degree? Which is more effective, sublingual pill, or sublingual liquid? And what is the rationale for choosing the sublingual liquid instead of the sublingual pill? What dosages should one take if taking both at the same time? (the Pregnenalone / DHEA combo is 9mg per dropperful of Pregnenalone and 15mg of DHEA. The DHEA / Pregnenalone Combo is 25mg of DHEA and 9mg of Pregnenalone). From my readings, these seem safe low dosages. (these are offered by Arrowhead Health Works in California). Since you still have to swallow after holding under the tongue for 1 minute, doesn’t it end up going through the liver anyway? Can ACE be taken along with these? And how effective do you believe this is in boosting one’s adrenal system? I would appreciate any input you could offer before I purchase.
Sublingual dosage often works quicker and may be more potent than intestinal absorption and may be less metabolized by the liver. If the tablets melt well under the tongue then the liquid and the tablet would be similar in potency. Care must be taken not to overdose on hormones.

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